Éva MONOSTORI
scientific adviser, Professor emerita, Group leade

picture
Ágnes CZIBULA research associate
Enikő SZABÓ research associate
Andrásné GERCSÓ scientific administrator

REGULATION OF IMMUNE RESPONSE IN AUTOIMMUNE DISEASES

Many factors participate in the regulation of peripheral immune tolerance and the maintenance of the immune homeostasis by controlling the inflammatory and autoimmune processes in mammals. On the other hand, cancer cells defend themselves against destructive tumor-specific immune response by producing immunosuppressive factors. A powerful mechanism in immune processes is the modulation of the pattern of cell surface glycosylation and the expression of soluble or cell-bound lectins interacting with their ligands. Among these lectins, galectin-1 is one of the master immunoregulators.

One form of the tissue stem cells, mesenchymal stem cells (MSC) possess powerful immunosuppressive activity. Hence these cells may be used as cellular therapeutical goods in immunological pathologies. Our studies on this field aim to have better insight into the immunoregulatory activity of MSCs.


MODELL SYSTEMS FOR IMPORTING THERAPEUTICAL PROTEIN AGENTS INTO THE CELLS

We work on modelling the import of protein active ingredients into the cells. We use proteins and cell penetrating peptides as vehicles and marker proteins as cargos. Vehicles and cargos are coupled with chemical synthesis or recombinant genetical means. Then the import and localization of the hybrid molecules are determined.


Application of the results of the research

MSC-s differentiate into cartilage. We use this property of MSCs for allogeneic MSC transplantation to treat dog osteoarthritis in a wide range open clinical study.

Selected publications

VAS V, FAJKA BOJA R, ION G, DUDICS V, MONOSTORI E, UHER F Biphasic effect of recombinant galectin-1 on the growth and death of early hematopoietic cells STEM CELLS, 23, 279-287 (2005)

ION G, FAJKA BOJA R, TOTH GK, CARON M, MONOSTORI E Role of p56(lck) and ZAP70-mediated tyrosine phosphorylation in galectin-1-induced cell death CELL DEATH DIFFER, 12, 1145-1147 (2005)

J KISS, A KUNSTÁR, R FAJKA-BOJA, V DUDICS, J TÓVÁRI, A LÉGRÁDI, E MONOSTORI, AND F UHER A novel anti-inflammatory function of human galectin-1: inhibition of hematopoietic progenitor cell mobilization. EXP. HEMATOL (2007) 35:305–31

VERONIKA S. URBÁN, JUDIT KISS, JÁNOS KOVÁCS, ELEN GÓCZA, VIRÁG VAS, EVA MONOSTORI, AND FERENC UHER Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes. STEMCELLS 2008;26:244–253

VALĖRIA DUDICS, ALIZ KUNSTÁR, JÁNOS KOVÁCS, TAMÁS LAKATOS, PÁL GÉHER, BELA GÖMÖR, ĖVA MONOSTORI, FERENC UHER Chondrogenic Potential of Mesenchymal Stem Cells from Patients with Rheumatoid Arthritis and Osteoarthritis: Measurements in a Microculture System. CELLS TISSUES ORGANS 2009;189:307–316

SZABÓ E, FAJKA-BOJA R, KRISTON-PÁL É, HORNUNG Á, MAKRA I, KUDLIK G, UHER F, KATONA RL, MONOSTORI É, CZIBULA Á. Licensing by Inflammatory Cytokines Abolishes Heterogeneity of Immunosuppressive Function of Mesenchymal Stem Cell Population. STEM CELLS DEV. 2015 Sep 15;24(18):2171-80

GJ SZEBENI, É KRISTON-PÁL, P BLAZSÓ, RL KATONA, J NOVÁK, E SZABÓ, Á CZIBULA, R FAJKA-BOJA, B HEGYI, F UHER, L KRENÁCS, G JOÓ, É MONOSTORI Identification of galectin-1 as a critical factor in function of mouse mesenchymal stromal cell-mediated tumor promotion PLOS ONE 2012;7(7):e41372

FAJKA-BOJA R, URBÁN VS, SZEBENI GJ, CZIBULA Á, BLASKÓ A, KRISTON-PÁL É, MAKRA I, HORNUNG Á, SZABÓ E, UHER F, THAN NG, MONOSTORI É. Galectin-1 is a local but not systemic immunomodulatory factor in mesenchymal stromal cells. CYTOTHERAPY. 2016 Mar;18(3):360-70

KRISTON PÁL É, CZIBULA Á, GYURIS Z, BALKA G, SEREGI A, FARKAS S, SÜTH M, KISS-TÓTH E, HARACSKA L, UHER F, MONOSTORI É. Characterization and therapeutical application of canine mesenchymal stem cells, CAN J VET RES. 2017 Jan;81(1):73-78.

HORNUNG A, MONOSTORI E AND KOVÁCS L Systemic lupus erythematosus in the light of the regulatory effect of galectin-1 on T-cell function LUPUS 26:(4) pp. 339-347. (2017)